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SMILES: C[C@@]1(CC2CC2)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncc(F)cc12

InChI Key: InChIKey=SCPFLRLBQJMUNG-QHCPKHFHSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 258418   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM258418
PNG
(US9505786, 5-2)
Show SMILES C[C@@]1(CC2CC2)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncc(F)cc12 |r|
Show InChI InChI=1S/C23H19F2N7O/c1-23(9-12-6-7-12)18-20(28-22(23)33)27-19(30-29-18)17-15-8-14(24)10-26-21(15)32(31-17)11-13-4-2-3-5-16(13)25/h2-5,8,10,12H,6-7,9,11H2,1H3,(H,27,28,30,33)/t23-/m0/s1
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US Patent
n/an/a 250n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...

US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair