BDBM25915 3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2k::indole sulfonamide, 8k
SMILES: NNC(=O)c1[nH]c2ccc(cc2c1-c1cccc(Br)c1)S(N)(=O)=O
InChI Key: InChIKey=LOUMFRZBAXRSLT-UHFFFAOYSA-N
Data: 15 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Carbonic Anhydrase XIV (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Carbonic Anhydrase (Caenorhabditis elegans) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 13.4 | -10.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Istanbul University | Assay Description An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol... | Bioorg Med Chem 17: 3212-5 (2009) Article DOI: 10.1016/j.bmc.2009.01.048 BindingDB Entry DOI: 10.7270/Q2MS3R3Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 54.1 | -9.91 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Carbonic Anhydrase XV (Mus musculus (mouse)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | KEGG GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 7 (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
beta-Carbonic Anhydrase (Candida albicans (Yeast)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 87 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University Curated by ChEMBL | Assay Description inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay | Bioorg Med Chem Lett 20: 2508-11 (2010) Article DOI: 10.1016/j.bmcl.2010.02.103 BindingDB Entry DOI: 10.7270/Q23F4PS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 510 | -8.58 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 682 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase VA (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase VB (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 858 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase XIII (Mus musculus (mouse)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 867 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 4 (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic Anhydrase III (Homo sapiens (Human)) | BDBM25915 (3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem 16: 9113-20 (2008) Article DOI: 10.1016/j.bmc.2008.09.032 BindingDB Entry DOI: 10.7270/Q2ZW1J7D | |||||||||||
More data for this Ligand-Target Pair |