BDBM259271 US9499547, 12

SMILES: NCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=MZQPJGSTVGHBDD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 259271   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) (Homo sapiens (Human))	BDBM259271 (US9499547, 12) Show SMILES NCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C16H14N4O2/c17-7-8-21-16-6-5-15-18-10-12(20(15)19-16)14-9-11-3-1-2-4-13(11)22-14/h1-6,9-10H,7-8,17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...				US Patent US9499547 (2016) BindingDB Entry DOI: 10.7270/Q2736PVK
					More data for this Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) (Homo sapiens (Human))	BDBM259271 (US9499547, 12) Show SMILES NCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C16H14N4O2/c17-7-8-21-16-6-5-15-18-10-12(20(15)19-16)14-9-11-3-1-2-4-13(11)22-14/h1-6,9-10H,7-8,17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US9499547 (2016) BindingDB Entry DOI: 10.7270/Q2736PVK
					More data for this Ligand-Target Pair