Found 8 hits for monomerid = 259446 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM259446
(US9512114, 5 | US9657007, Example 5)Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.
US Patent
| Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ... |
US Patent US9512114 (2016)
BindingDB Entry DOI: 10.7270/Q2TT4PWS |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM259446
(US9512114, 5 | US9657007, Example 5)Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 259 | n/a | n/a | n/a | n/a | n/a | 25 |
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.
US Patent
| Assay Description PI3K (p1103/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as requ... |
US Patent US9512114 (2016)
BindingDB Entry DOI: 10.7270/Q2TT4PWS |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM259446
(US9512114, 5 | US9657007, Example 5)Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | 25 |
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.
US Patent
| Assay Description PI3K (p110δ/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as... |
US Patent US9512114 (2016)
BindingDB Entry DOI: 10.7270/Q2TT4PWS |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM259446
(US9512114, 5 | US9657007, Example 5)Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 388 | n/a | n/a | n/a | n/a | n/a | n/a |
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.
US Patent
| |
US Patent US9657007 (2017)
BindingDB Entry DOI: 10.7270/Q2J10574 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM259446
(US9512114, 5 | US9657007, Example 5)Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.
US Patent
| |
US Patent US9657007 (2017)
BindingDB Entry DOI: 10.7270/Q2J10574 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM259446
(US9512114, 5 | US9657007, Example 5)Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 259 | n/a | n/a | n/a | n/a | n/a | n/a |
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.
US Patent
| |
US Patent US9657007 (2017)
BindingDB Entry DOI: 10.7270/Q2J10574 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM259446
(US9512114, 5 | US9657007, Example 5)Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.
US Patent
| Assay Description Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ... |
US Patent US9657007 (2017)
BindingDB Entry DOI: 10.7270/Q2J10574 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM259446
(US9512114, 5 | US9657007, Example 5)Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C25H22ClN7O2/c1-3-18(30-23-21(22(27)28-13-29-23)24-32-31-14(2)35-24)19-12-15-8-7-11-17(26)20(15)25(34)33(19)16-9-5-4-6-10-16/h4-13,18H,3H2,1-2H3,(H3,27,28,29,30)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 388 | n/a | n/a | n/a | n/a | n/a | 25 |
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.
US Patent
| Assay Description PI3K (p120γ) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as required)... |
US Patent US9512114 (2016)
BindingDB Entry DOI: 10.7270/Q2TT4PWS |
More data for this Ligand-Target Pair | |