BDBM259819 US9505766, 20

SMILES: CS(=O)(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N

InChI Key: InChIKey=NUTCBXHBYDJNKL-WUXMJOGZSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 259819   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ribosomal S6 kinase 2 (RSK-2) (Homo sapiens (Human))	BDBM259819 (US9505766, 20) Show SMILES CS(=O)(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N Show InChI InChI=1S/C15H11N5O2S/c1-23(21,22)12(7-16)6-10-2-4-11(5-3-10)13-14-15(19-8-17-13)20-9-18-14/h2-6,8-9H,1H3,(H,17,18,19,20)/b12-6+	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	8.0	22
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent					Assay Description RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...				US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A) (Homo sapiens (Human))	BDBM259819 (US9505766, 20) Show SMILES CS(=O)(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N Show InChI InChI=1S/C15H11N5O2S/c1-23(21,22)12(7-16)6-10-2-4-11(5-3-10)13-14-15(19-8-17-13)20-9-18-14/h2-6,8-9H,1H3,(H,17,18,19,20)/b12-6+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.6	25
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent					Assay Description For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...				US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A) (Homo sapiens (Human))	BDBM259819 (US9505766, 20) Show SMILES CS(=O)(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N Show InChI InChI=1S/C15H11N5O2S/c1-23(21,22)12(7-16)6-10-2-4-11(5-3-10)13-14-15(19-8-17-13)20-9-18-14/h2-6,8-9H,1H3,(H,17,18,19,20)/b12-6+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	7.6	25
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent					Assay Description For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...				US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR
					More data for this Ligand-Target Pair