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SMILES: CNC(=O)C(=C\C1CCN(CC1)c1ncnc2[nH]cnc12)\C#N

InChI Key: InChIKey=GVDKYWUWIBMHLJ-IZZDOVSWSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 259832   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Nek2 [T175A]


(Homo sapiens (Human))		BDBM259832
PNG
(US9505766, 36)
Show SMILES CNC(=O)C(=C\C1CCN(CC1)c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H17N7O/c1-17-15(23)11(7-16)6-10-2-4-22(5-3-10)14-12-13(19-8-18-12)20-9-21-14/h6,8-10H,2-5H2,1H3,(H,17,23)(H,18,19,20,21)/b11-6+
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 440n/an/an/an/a7.625



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...

US Patent US9505766 (2016)


BindingDB Entry DOI: 10.7270/Q2639NPR
More data for this
Ligand-Target Pair