null

SMILES: COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C1CC1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key: InChIKey=ZNJMXQJKVYQJOK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 261151   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261151 (5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C1CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C26H28ClN7O2/c1-13-20(27)9-19(15(3)34-25-22(14(2)32-34)24(28)30-12-31-25)23(36-5)21(13)16-8-17(11-29-10-16)26(35)33(4)18-6-7-18/h8-12,15,18H,6-7H2,1-5H3,(H2,28,30,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261151 (5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C1CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C26H28ClN7O2/c1-13-20(27)9-19(15(3)34-25-22(14(2)32-34)24(28)30-12-31-25)23(36-5)21(13)16-8-17(11-29-10-16)26(35)33(4)18-6-7-18/h8-12,15,18H,6-7H2,1-5H3,(H2,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...				US Patent US10646492 (2020)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261151 (5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C1CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C26H28ClN7O2/c1-13-20(27)9-19(15(3)34-25-22(14(2)32-34)24(28)30-12-31-25)23(36-5)21(13)16-8-17(11-29-10-16)26(35)33(4)18-6-7-18/h8-12,15,18H,6-7H2,1-5H3,(H2,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10376513 (2019) BindingDB Entry DOI: 10.7270/Q2GQ7142
					More data for this Ligand-Target Pair