BDBM261158 1-(1-(5-Chloro-2-methoxy-4-methyl-3-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)phenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine::US10092570, Example 181::US10376513, Example 181::US10646492, Example 181::US9707233, 181::US9730939, Example 181

SMILES: COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key: InChIKey=VZUKFCYWZYFFIL-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 261158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110delta/p85alpha (Homo sapiens (Human))	BDBM261158 (1-(1-(5-Chloro-2-methoxy-4-methyl-3-(1-(1-methylpi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H31ClN8O/c1-14-20(26)10-19(16(3)34-25-22(15(2)31-34)24(27)28-13-29-25)23(35-5)21(14)17-11-30-33(12-17)18-6-8-32(4)9-7-18/h10-13,16,18H,6-9H2,1-5H3,(H2,27,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261158 (1-(1-(5-Chloro-2-methoxy-4-methyl-3-(1-(1-methylpi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H31ClN8O/c1-14-20(26)10-19(16(3)34-25-22(15(2)31-34)24(27)28-13-29-25)23(35-5)21(14)17-11-30-33(12-17)18-6-8-32(4)9-7-18/h10-13,16,18H,6-9H2,1-5H3,(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10092570 (2018) BindingDB Entry DOI: 10.7270/Q2PZ5BW5
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261158 (1-(1-(5-Chloro-2-methoxy-4-methyl-3-(1-(1-methylpi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H31ClN8O/c1-14-20(26)10-19(16(3)34-25-22(15(2)31-34)24(27)28-13-29-25)23(35-5)21(14)17-11-30-33(12-17)18-6-8-32(4)9-7-18/h10-13,16,18H,6-9H2,1-5H3,(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...				US Patent US10646492 (2020)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261158 (1-(1-(5-Chloro-2-methoxy-4-methyl-3-(1-(1-methylpi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H31ClN8O/c1-14-20(26)10-19(16(3)34-25-22(15(2)31-34)24(27)28-13-29-25)23(35-5)21(14)17-11-30-33(12-17)18-6-8-32(4)9-7-18/h10-13,16,18H,6-9H2,1-5H3,(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10376513 (2019) BindingDB Entry DOI: 10.7270/Q2GQ7142
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261158 (1-(1-(5-Chloro-2-methoxy-4-methyl-3-(1-(1-methylpi...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C25H31ClN8O/c1-14-20(26)10-19(16(3)34-25-22(15(2)31-34)24(27)28-13-29-25)23(35-5)21(14)17-11-30-33(12-17)18-6-8-32(4)9-7-18/h10-13,16,18H,6-9H2,1-5H3,(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...				US Patent US9730939 (2017) BindingDB Entry DOI: 10.7270/Q2GB265W
					More data for this Ligand-Target Pair