BDBM26161 2,4-dianilino pyrimidine, 18::3-[(4-{[5-(aminomethyl)-2-methylphenyl]amino}pyrimidin-2-yl)amino]benzamide

SMILES: Cc1ccc(CN)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1

InChI Key: InChIKey=PUICRHPFLMHXCN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26161   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lck (Mus musculus)	BDBM26161 (2,4-dianilino pyrimidine, 18 | 3-[(4-{[5-(aminomet...) Show SMILES Cc1ccc(CN)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C19H20N6O/c1-12-5-6-13(11-20)9-16(12)24-17-7-8-22-19(25-17)23-15-4-2-3-14(10-15)18(21)26/h2-10H,11,20H2,1H3,(H2,21,26)(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair