BDBM26171 2,4-dianilino pyrimidine, 28::3-{[4-(1H-indazol-5-ylamino)pyrimidin-2-yl]amino}benzamide

SMILES: NC(=O)c1cccc(Nc2nccc(Nc3ccc4[nH]ncc4c3)n2)c1

InChI Key: InChIKey=QVGRISFHWIHDLD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26171   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lck (Mus musculus)	BDBM26171 (2,4-dianilino pyrimidine, 28 | 3-{[4-(1H-indazol-5...) Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3ccc4[nH]ncc4c3)n2)c1 Show InChI InChI=1S/C18H15N7O/c19-17(26)11-2-1-3-13(8-11)23-18-20-7-6-16(24-18)22-14-4-5-15-12(9-14)10-21-25-15/h1-10H,(H2,19,26)(H,21,25)(H2,20,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair