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SMILES: NC(=O)c1cccc(Nc2nccc(Nc3cccc4ncccc34)n2)c1

InChI Key: InChIKey=MODRKXWTPQZUGE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26175   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase LCK


(Mus musculus)		BDBM26175
PNG
(2,4-dianilino pyrimidine, 32 | 3-{[4-(quinolin-5-y...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc4ncccc34)n2)c1
Show InChI InChI=1S/C20H16N6O/c21-19(27)13-4-1-5-14(12-13)24-20-23-11-9-18(26-20)25-17-8-2-7-16-15(17)6-3-10-22-16/h1-12H,(H2,21,27)(H2,23,24,25,26)
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n/an/a 560n/an/an/an/an/an/a



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...

Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair