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BDBM26185 2,4-dianilino pyrimidine, 42::3-{[4-(1H-indazol-4-ylamino)pyrimidin-2-yl]amino}benzene-1-sulfonamide::GTC000120A

SMILES: NS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1

InChI Key: InChIKey=KVSWEQSTPCJTSJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26185   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lck


(Mus musculus)
BDBM26185
PNG
(2,4-dianilino pyrimidine, 42 | 3-{[4-(1H-indazol-4...)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1
Show InChI InChI=1S/C17H15N7O2S/c18-27(25,26)12-4-1-3-11(9-12)21-17-19-8-7-16(23-17)22-14-5-2-6-15-13(14)10-20-24-15/h1-10H,(H,20,24)(H2,18,25,26)(H2,19,21,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)

More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM26185
PNG
(2,4-dianilino pyrimidine, 42 | 3-{[4-(1H-indazol-4...)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1
Show InChI InChI=1S/C17H15N7O2S/c18-27(25,26)12-4-1-3-11(9-12)21-17-19-8-7-16(23-17)22-14-5-2-6-15-13(14)10-20-24-15/h1-10H,(H,20,24)(H2,18,25,26)(H2,19,21,22,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

D3R
n/an/a 47.5n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


Citation and Details
More data for this
Ligand-Target Pair
SYK Kinase


(Homo sapiens (Human))
BDBM26185
PNG
(2,4-dianilino pyrimidine, 42 | 3-{[4-(1H-indazol-4...)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1
Show InChI InChI=1S/C17H15N7O2S/c18-27(25,26)12-4-1-3-11(9-12)21-17-19-8-7-16(23-17)22-14-5-2-6-15-13(14)10-20-24-15/h1-10H,(H,20,24)(H2,18,25,26)(H2,19,21,22,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

D3R
n/an/a 18n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


Citation and Details
More data for this
Ligand-Target Pair