BDBM26319 2-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]-N-[3-(trifluoromethyl)phenyl]acetamide::thieno[3,2-d]pyrimidine analogue, 14

SMILES: FC(F)(F)c1cccc(NC(=O)Cc2ncc(CCNc3ncnc4ccsc34)s2)c1

InChI Key: InChIKey=USSPDYYDWFNICI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26319   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM26319 (2-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...) Show SMILES FC(F)(F)c1cccc(NC(=O)Cc2ncc(CCNc3ncnc4ccsc34)s2)c1 Show InChI InChI=1S/C20H16F3N5OS2/c21-20(22,23)12-2-1-3-13(8-12)28-16(29)9-17-25-10-14(31-17)4-6-24-19-18-15(5-7-30-18)26-11-27-19/h1-3,5,7-8,10-11H,4,6,9H2,(H,28,29)(H,24,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	442	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals					Assay Description Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...				Bioorg Med Chem Lett 18: 4880-4 (2008) Article DOI: 10.1016/j.bmcl.2008.07.073 BindingDB Entry DOI: 10.7270/Q279430N
					More data for this Ligand-Target Pair
Aurora Kinase A (Aurora-A) (Mus musculus (mouse))	BDBM26319 (2-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...) Show SMILES FC(F)(F)c1cccc(NC(=O)Cc2ncc(CCNc3ncnc4ccsc34)s2)c1 Show InChI InChI=1S/C20H16F3N5OS2/c21-20(22,23)12-2-1-3-13(8-12)28-16(29)9-17-25-10-14(31-17)4-6-24-19-18-15(5-7-30-18)26-11-27-19/h1-3,5,7-8,10-11H,4,6,9H2,(H,28,29)(H,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	7.2	21
Sunesis Pharmaceuticals					Assay Description Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...				Bioorg Med Chem Lett 18: 4880-4 (2008) Article DOI: 10.1016/j.bmcl.2008.07.073 BindingDB Entry DOI: 10.7270/Q279430N
					More data for this Ligand-Target Pair