BDBM263285 1-[6-((r)-2-methyl-pyrrolidin-1-yl)-pyridin-3-ylmethyl]-3-trifluoromethyl-1h-pyrazole-4-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide::US9533987, example 63
SMILES: C[C@@H]1CCCN1c1ccc(Cn2cc(C(=O)NCc3ccc4c(N)nccc4c3)c(n2)C(F)(F)F)cn1
InChI Key: InChIKey=DSSWHEZOLVGIOD-MRXNPFEDSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kallikrein 1 (Homo sapiens (Human)) | BDBM263285 (1-[6-((r)-2-methyl-pyrrolidin-1-yl)-pyridin-3-ylme...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kalvista Pharmaceuticals Limited US Patent | Assay Description Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge... | US Patent US9533987 (2017) BindingDB Entry DOI: 10.7270/Q2SX6G78 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasma kallikrein (Homo sapiens (Human)) | BDBM263285 (1-[6-((r)-2-methyl-pyrrolidin-1-yl)-pyridin-3-ylme...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kalvista Pharmaceuticals Limited US Patent | Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8... | US Patent US9533987 (2017) BindingDB Entry DOI: 10.7270/Q2SX6G78 | |||||||||||
More data for this Ligand-Target Pair |