BDBM26380 1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)benzene-1,3-dicarboxamide::Aminopyrimidine amide, 17

SMILES: COc1ccccc1C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1

InChI Key: InChIKey=GYXYRHICZGGSGP-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26380   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26380 (1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...) Show SMILES COc1ccccc1C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C31H33N7O3/c1-21-8-9-23(34-29(39)26-6-4-5-7-28(26)41-3)18-27(21)30(40)35-24-19-32-31(33-20-24)36-22-10-12-25(13-11-22)38-16-14-37(2)15-17-38/h4-13,18-20H,14-17H2,1-3H3,(H,34,39)(H,35,40)(H,32,33,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM26380 (1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...) Show SMILES COc1ccccc1C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C31H33N7O3/c1-21-8-9-23(34-29(39)26-6-4-5-7-28(26)41-3)18-27(21)30(40)35-24-19-32-31(33-20-24)36-22-10-12-25(13-11-22)38-16-14-37(2)15-17-38/h4-13,18-20H,14-17H2,1-3H3,(H,34,39)(H,35,40)(H,32,33,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM26380 (1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...) Show SMILES COc1ccccc1C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C31H33N7O3/c1-21-8-9-23(34-29(39)26-6-4-5-7-28(26)41-3)18-27(21)30(40)35-24-19-32-31(33-20-24)36-22-10-12-25(13-11-22)38-16-14-37(2)15-17-38/h4-13,18-20H,14-17H2,1-3H3,(H,34,39)(H,35,40)(H,32,33,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26380 (1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...) Show SMILES COc1ccccc1C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C31H33N7O3/c1-21-8-9-23(34-29(39)26-6-4-5-7-28(26)41-3)18-27(21)30(40)35-24-19-32-31(33-20-24)36-22-10-12-25(13-11-22)38-16-14-37(2)15-17-38/h4-13,18-20H,14-17H2,1-3H3,(H,34,39)(H,35,40)(H,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26380 (1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...) Show SMILES COc1ccccc1C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C31H33N7O3/c1-21-8-9-23(34-29(39)26-6-4-5-7-28(26)41-3)18-27(21)30(40)35-24-19-32-31(33-20-24)36-22-10-12-25(13-11-22)38-16-14-37(2)15-17-38/h4-13,18-20H,14-17H2,1-3H3,(H,34,39)(H,35,40)(H,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair