BDBM26385 1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)benzene-1,3-dicarboxamide::Aminopyrimidine amide, 22

SMILES: COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1

InChI Key: InChIKey=IRPDQNYYMPGXNV-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26385   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26385 (1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...) Show SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C32H35N7O4/c1-21-5-6-24(35-30(40)22-15-27(42-3)18-28(16-22)43-4)17-29(21)31(41)36-25-19-33-32(34-20-25)37-23-7-9-26(10-8-23)39-13-11-38(2)12-14-39/h5-10,15-20H,11-14H2,1-4H3,(H,35,40)(H,36,41)(H,33,34,37)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM26385 (1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...) Show SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C32H35N7O4/c1-21-5-6-24(35-30(40)22-15-27(42-3)18-28(16-22)43-4)17-29(21)31(41)36-25-19-33-32(34-20-25)37-23-7-9-26(10-8-23)39-13-11-38(2)12-14-39/h5-10,15-20H,11-14H2,1-4H3,(H,35,40)(H,36,41)(H,33,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM26385 (1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...) Show SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C32H35N7O4/c1-21-5-6-24(35-30(40)22-15-27(42-3)18-28(16-22)43-4)17-29(21)31(41)36-25-19-33-32(34-20-25)37-23-7-9-26(10-8-23)39-13-11-38(2)12-14-39/h5-10,15-20H,11-14H2,1-4H3,(H,35,40)(H,36,41)(H,33,34,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26385 (1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...) Show SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C32H35N7O4/c1-21-5-6-24(35-30(40)22-15-27(42-3)18-28(16-22)43-4)17-29(21)31(41)36-25-19-33-32(34-20-25)37-23-7-9-26(10-8-23)39-13-11-38(2)12-14-39/h5-10,15-20H,11-14H2,1-4H3,(H,35,40)(H,36,41)(H,33,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26385 (1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...) Show SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C32H35N7O4/c1-21-5-6-24(35-30(40)22-15-27(42-3)18-28(16-22)43-4)17-29(21)31(41)36-25-19-33-32(34-20-25)37-23-7-9-26(10-8-23)39-13-11-38(2)12-14-39/h5-10,15-20H,11-14H2,1-4H3,(H,35,40)(H,36,41)(H,33,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair