BDBM264268 8-(3-Aminoprop-1-yn-1-yl)-6-(2,6-dichlorophenyl)-2-((4-morpholinophenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one::US9714244, 22

SMILES: NCC#Cc1cn(-c2c(Cl)cccc2Cl)c(=O)c2cnc(Nc3ccc(cc3)N3CCOCC3)nc12

InChI Key: InChIKey=JDJCNZJDYZFLQE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 264268   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM264268 (8-(3-Aminoprop-1-yn-1-yl)-6-(2,6-dichlorophenyl)-2...) Show SMILES NCC#Cc1cn(-c2c(Cl)cccc2Cl)c(=O)c2cnc(Nc3ccc(cc3)N3CCOCC3)nc12 |(2.67,-5.39,;4,-4.62,;4,-3.08,;4,-1.54,;4,,;5.33,.77,;5.33,2.31,;6.67,3.08,;6.67,4.62,;5.33,5.39,;8,5.39,;9.34,4.62,;9.34,3.08,;8,2.31,;8,.77,;4,3.08,;4,4.62,;2.67,2.31,;1.33,3.08,;,2.31,;,.77,;-1.33,,;-2.67,.77,;-4,,;-5.33,.77,;-5.33,2.31,;-4,3.08,;-2.67,2.31,;-6.67,3.08,;-8,2.31,;-9.34,3.08,;-9.34,4.62,;-8,5.39,;-6.67,4.62,;1.33,,;2.67,.77,)| Show InChI InChI=1S/C26H22Cl2N6O2/c27-21-4-1-5-22(28)24(21)34-16-17(3-2-10-29)23-20(25(34)35)15-30-26(32-23)31-18-6-8-19(9-7-18)33-11-13-36-14-12-33/h1,4-9,15-16H,10-14,29H2,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
ALMAC DISCOVERY LIMITED US Patent					Assay Description In the measurement of Wee-1 activity, a commercial peptide Poly(Lys Tyr(4:1)) hydrobromide was purchased from Sigma Aldrich and used as the substrate...				US Patent US9714244 (2017) BindingDB Entry DOI: 10.7270/Q2GH9KZ4
					More data for this Ligand-Target Pair