BDBM26428 ethyl (2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)amino]imidazo[1,2-a]pyrimidin-5-yl}amino)methyl]phenyl}prop-2-enoate::imidazo[1,2-c]pyrimidine-8-carboxamide, 26

SMILES: CCOC(=O)\C=C\c1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1

InChI Key: InChIKey=HIMWQCHCBXPDBE-MDZDMXLPSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26428 (ethyl (2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyph...) Show SMILES CCOC(=O)\C=C\c1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1 Show InChI InChI=1S/C27H28N6O5/c1-4-38-22(34)10-9-17-5-7-18(8-6-17)16-30-27-32-25(23(24(28)35)26-29-11-12-33(26)27)31-19-13-20(36-2)15-21(14-19)37-3/h5-15,31H,4,16H2,1-3H3,(H2,28,35)(H,30,32)/b10-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26428 (ethyl (2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyph...) Show SMILES CCOC(=O)\C=C\c1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1 Show InChI InChI=1S/C27H28N6O5/c1-4-38-22(34)10-9-17-5-7-18(8-6-17)16-30-27-32-25(23(24(28)35)26-29-11-12-33(26)27)31-19-13-20(36-2)15-21(14-19)37-3/h5-15,31H,4,16H2,1-3H3,(H2,28,35)(H,30,32)/b10-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair