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BDBM2650 (Phenylindolyl)maleimide deriv. 72::3-(1-methyl-1H-indol-3-yl)-4-(2-methylphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione

SMILES: Cc1ccccc1C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12

InChI Key: InChIKey=CIXYARKGFUUHHW-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 8 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 2650   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2650
PNG
((Phenylindolyl)maleimide deriv. 72 | 3-(1-methyl-1...)
Show SMILES Cc1ccccc1C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12 |t:8|
Show InChI InChI=1S/C20H16N2O2/c1-12-7-3-4-8-13(12)17-18(20(24)21-19(17)23)15-11-22(2)16-10-6-5-9-14(15)16/h3-11H,1-2H3,(H,21,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1016/j.bmc.2005.03.050
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair