BDBM26535 (1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-methyl-4-oxo-5-azaspiro[2.4]heptane-1-carboxylic acid::carboxylate-spirocyclopropyl compound, 20

SMILES: CN1C(C[C@@]2(C[C@@H]2C(O)=O)C1=O)c1ccc(OCc2cc(nc3ccccc23)-c2ccccc2)c(F)c1

InChI Key: InChIKey=INJZRGNTMDWYSJ-YDSPQXFFSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26535   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q] (Homo sapiens (Human))	BDBM26535 ((1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)meth...) Show SMILES CN1C(C[C@@]2(C[C@@H]2C(O)=O)C1=O)c1ccc(OCc2cc(nc3ccccc23)-c2ccccc2)c(F)c1 |r| Show InChI InChI=1S/C30H25FN2O4/c1-33-26(16-30(29(33)36)15-22(30)28(34)35)19-11-12-27(23(31)13-19)37-17-20-14-25(18-7-3-2-4-8-18)32-24-10-6-5-9-21(20)24/h2-14,22,26H,15-17H2,1H3,(H,34,35)/t22-,26?,30-/m1/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	94	-9.48	n/a	n/a	n/a	n/a	n/a	7.3	22
Schering-Plough Research Institute					Assay Description Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...				Bioorg Med Chem Lett 19: 54-7 (2009) Article DOI: 10.1016/j.bmcl.2008.11.034 BindingDB Entry DOI: 10.7270/Q2JH3JH7
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