BDBM26623 (5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolidine-2,4-dione::US8637558, 41::thiazolidine-2,4-dione, 1a
SMILES: Cc1ccc(C=C2SC(O)=NC2=O)cc1
InChI Key: InChIKey=VUXDSWRSGDQYRJ-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM26623 ((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Medical University of South Carolina | Assay Description The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin... | J Med Chem 52: 74-86 (2009) Article DOI: 10.1021/jm800937p BindingDB Entry DOI: 10.7270/Q2S180SF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
15-hydroxyprostaglandin dehydrogenase [NAD+] (Homo sapiens (Human)) | BDBM26623 ((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 5.82E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Industry-Academic Cooperation Foundation, Chosun University US Patent | Assay Description Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s... | US Patent US8637558 (2014) BindingDB Entry DOI: 10.7270/Q280519F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM26623 ((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of South Carolina | Assay Description The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin... | J Med Chem 52: 74-86 (2009) Article DOI: 10.1021/jm800937p BindingDB Entry DOI: 10.7270/Q2S180SF | |||||||||||
More data for this Ligand-Target Pair |