BDBM26675 4-(2-hydroxy-5-methylphenyl)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile::pyridone-based compound, 3

SMILES: Cc1ccc(O)c(c1)-c1cc([nH]c(=O)c1C#N)-c1ccccc1

InChI Key: InChIKey=KCGDXRXRKTWLTG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26675   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM26675 (4-(2-hydroxy-5-methylphenyl)-2-oxo-6-phenyl-1,2-di...) Show SMILES Cc1ccc(O)c(c1)-c1cc([nH]c(=O)c1C#N)-c1ccccc1 Show InChI InChI=1S/C19H14N2O2/c1-12-7-8-18(22)15(9-12)14-10-17(13-5-3-2-4-6-13)21-19(23)16(14)11-20/h2-10,22H,1H3,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	7.5	23
Valeant Pharmaceuticals Research and Development					Assay Description PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...				Bioorg Med Chem Lett 17: 1679-83 (2007) Article DOI: 10.1016/j.bmcl.2006.12.086 BindingDB Entry DOI: 10.7270/Q2CV4G2V
					More data for this Ligand-Target Pair