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SMILES: FC(F)(F)c1cc([nH]c(=O)c1C#N)-c1ccco1

InChI Key: InChIKey=HKJBZVGQPULVPE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26681   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26681
PNG
(6-(furan-2-yl)-2-oxo-4-(trifluoromethyl)-1,2-dihyd...)
Show SMILES FC(F)(F)c1cc([nH]c(=O)c1C#N)-c1ccco1
Show InChI InChI=1S/C11H5F3N2O2/c12-11(13,14)7-4-8(9-2-1-3-18-9)16-10(17)6(7)5-15/h1-4H,(H,16,17)
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MMDB

KEGG

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair