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SMILES: Nc1n[nH]c2nc(cc(-c3ccccc3)c12)-c1cc(Br)ccc1O

InChI Key: InChIKey=CZDDKQGCFAHRBQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26683   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26683
PNG
(2-{3-amino-4-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl...)
Show SMILES Nc1n[nH]c2nc(cc(-c3ccccc3)c12)-c1cc(Br)ccc1O
Show InChI InChI=1S/C18H13BrN4O/c19-11-6-7-15(24)13(8-11)14-9-12(10-4-2-1-3-5-10)16-17(20)22-23-18(16)21-14/h1-9,24H,(H3,20,21,22,23)
PDB
MMDB

KEGG

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.77E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair