BDBM267390 3-chloro-5-((1-((5-(4- fluorophenyl)-6-oxo- 1,6-dihydropyridazin- 3-yl)methyl)-4- methyl-6-oxo-1,6- dihydropyrimidin-5- yl)oxy)benzonitrile::US10189831, Example 166::US9718819, 166

SMILES: FC(F)Oc1ncn(Cc2cc(-c3ccc(F)cc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N

InChI Key: InChIKey=JEVSYGZBOKEQFO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267390   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM267390 (3-chloro-5-((1-((5-(4- fluorophenyl)-6-oxo- 1,6-di...) Show SMILES FC(F)Oc1ncn(Cc2cc(-c3ccc(F)cc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N Show InChI InChI=1S/C23H13ClF3N5O4/c24-14-5-12(9-28)6-17(7-14)35-19-21(36-23(26)27)29-11-32(22(19)34)10-16-8-18(20(33)31-30-16)13-1-3-15(25)4-2-13/h1-8,11,23H,10H2,(H,31,33)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...				US Patent US10189831 (2019) BindingDB Entry DOI: 10.7270/Q2QF8VZJ
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM267390 (3-chloro-5-((1-((5-(4- fluorophenyl)-6-oxo- 1,6-di...) Show SMILES FC(F)Oc1ncn(Cc2cc(-c3ccc(F)cc3)c(=O)[nH]n2)c(=O)c1Oc1cc(Cl)cc(c1)C#N Show InChI InChI=1S/C23H13ClF3N5O4/c24-14-5-12(9-28)6-17(7-14)35-19-21(36-23(26)27)29-11-32(22(19)34)10-16-8-18(20(33)31-30-16)13-1-3-15(25)4-2-13/h1-8,11,23H,10H2,(H,31,33)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.8	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...				US Patent US9718819 (2017) BindingDB Entry DOI: 10.7270/Q2WM1GDF
					More data for this Ligand-Target Pair