null

SMILES: CCc1cnc(NC(=O)c2ccc(cc2)-c2nc([C@H]3CC[C@H](O)CC3)n3ccnc(N)c23)s1

InChI Key: InChIKey=NHCYDZJWKSBDDK-JCNLHEQBSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM267474 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) Show SMILES CCc1cnc(NC(=O)c2ccc(cc2)-c2nc([C@H]3CC[C@H](O)CC3)n3ccnc(N)c23)s1 |r,wU:18.18,wD:21.22,(1.19,10.33,;2.68,9.93,;3.07,8.44,;4.54,7.97,;4.54,6.43,;3.07,5.95,;2.68,4.46,;1.19,4.06,;.1,5.15,;.79,2.58,;1.88,1.49,;1.48,,;-.01,-.4,;-1.1,.69,;-.7,2.18,;-.41,-1.89,;.5,-3.13,;-.41,-4.38,;-.01,-5.87,;1.48,-6.26,;1.88,-7.75,;.79,-8.84,;1.19,-10.33,;-.7,-8.44,;-1.1,-6.95,;-1.87,-3.9,;-3.2,-4.67,;-4.54,-3.9,;-4.54,-2.36,;-3.2,-1.59,;-3.2,-.05,;-1.87,-2.36,;2.17,7.2,)| Show InChI InChI=1S/C24H26N6O2S/c1-2-18-13-27-24(33-18)29-23(32)16-5-3-14(4-6-16)19-20-21(25)26-11-12-30(20)22(28-19)15-7-9-17(31)10-8-15/h3-6,11-13,15,17,31H,2,7-10H2,1H3,(H2,25,26)(H,27,29,32)/t15-,17-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	7.2	25
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent					Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...				US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T
					More data for this Ligand-Target Pair