null

SMILES: Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H]3CC[C@H](O)CC3)n3ccnc(N)c23)c1

InChI Key: InChIKey=LFXCFKCQTRPVEM-UAPYVXQJSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267475   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM267475 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H]3CC[C@H](O)CC3)n3ccnc(N)c23)c1 |r,wU:18.18,wD:21.22,(1.08,9.97,;2.17,8.88,;3.66,9.28,;4.75,8.19,;4.35,6.7,;2.86,6.31,;2.46,4.82,;.98,4.42,;-.11,5.51,;.58,2.93,;1.67,1.84,;1.27,.36,;-.22,-.04,;-1.31,1.05,;-.91,2.53,;-.62,-1.53,;.29,-2.78,;-.62,-4.02,;-.22,-5.51,;1.27,-5.91,;1.67,-7.4,;.58,-8.48,;.98,-9.97,;-.91,-8.09,;-1.31,-6.6,;-2.08,-3.55,;-3.42,-4.32,;-4.75,-3.55,;-4.75,-2.01,;-3.42,-1.24,;-3.42,.3,;-2.08,-2.01,;1.77,7.4,)| Show InChI InChI=1S/C25H26N6O2/c1-15-10-11-27-20(14-15)29-25(33)18-4-2-16(3-5-18)21-22-23(26)28-12-13-31(22)24(30-21)17-6-8-19(32)9-7-17/h2-5,10-14,17,19,32H,6-9H2,1H3,(H2,26,28)(H,27,29,33)/t17-,19-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	7.2	25
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent					Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...				US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T
					More data for this Ligand-Target Pair