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SMILES: Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C1CCOCC1

InChI Key: InChIKey=RWDZGVZFIZGWEY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267496   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM267496
PNG
(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo [1,...)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C1CCOCC1
Show InChI InChI=1S/C24H21F3N6O2/c25-24(26,27)17-5-8-29-18(13-17)31-23(34)16-3-1-14(2-4-16)19-20-21(28)30-9-10-33(20)22(32-19)15-6-11-35-12-7-15/h1-5,8-10,13,15H,6-7,11-12H2,(H2,28,30)(H,29,31,34)
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MMDB

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UniChem
US Patent
n/an/an/an/a<10n/an/a7.225



MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V.

US Patent


Assay Description
Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...

US Patent US9718828 (2017)


BindingDB Entry DOI: 10.7270/Q2H9977T
More data for this
Ligand-Target Pair