BDBM267528 (R)-4-(8-amino-3-(1-(3,3-difluorocyclobutanecarbonyl) piperidin-3-yl)imidazo[1,5-a] pyrazin-1-yl)-N-(4-cyclopropylpyridin-2-yl)benzamide ::US9718828, Example, 110
SMILES: Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C3CC3)c12)[C@@H]1CCCN(C1)C(=O)CN1CCOC1=O
InChI Key: InChIKey=SYRJZYXLLNMEGR-HSZRJFAPSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267528 ((R)-4-(8-amino-3-(1-(3,3-difluorocyclobutanecarbon...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair |