BDBM267898 4-(8-amino-3-{(2R)-4-[(3-methyloxetan-3-yl)carbonyl]morpholin-2-yl}imidazo[1,5-a]pyrazin-1-yl)-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide::US9718828, Example, 514

SMILES: Cc1cnc(N)c2c(nc([C@H]3CN(CCO3)C(=O)C3(C)COC3)n12)-c1ccc(cc1F)C(=O)Nc1cc(ccn1)C(F)(F)F

InChI Key: InChIKey=BWPJHIFJHWKZPB-HXUWFJFHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267898   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM267898 (4-(8-amino-3-{(2R)-4-[(3-methyloxetan-3-yl)carbony...) Show SMILES Cc1cnc(N)c2c(nc([C@H]3CN(CCO3)C(=O)C3(C)COC3)n12)-c1ccc(cc1F)C(=O)Nc1cc(ccn1)C(F)(F)F |r| Show InChI InChI=1S/C29H27F4N7O4/c1-15-11-36-24(34)23-22(38-25(40(15)23)20-12-39(7-8-44-20)27(42)28(2)13-43-14-28)18-4-3-16(9-19(18)30)26(41)37-21-10-17(5-6-35-21)29(31,32)33/h3-6,9-11,20H,7-8,12-14H2,1-2H3,(H2,34,36)(H,35,37,41)/t20-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent					Assay Description BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...				US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T
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