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BDBM2679 3,4-bis(2-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::Bisindolyl deriv. 9

SMILES: Cc1[nH]c2ccccc2c1C1=C(C(=O)NC1=O)c1c(C)[nH]c2ccccc12

InChI Key: InChIKey=NSVKLEKFZHEGLS-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 2679   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2679
PNG
(3,4-bis(2-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyr...)
Show SMILES Cc1[nH]c2ccccc2c1C1=C(C(=O)NC1=O)c1c(C)[nH]c2ccccc12 |t:12|
Show InChI InChI=1S/C22H17N3O2/c1-11-17(13-7-3-5-9-15(13)23-11)19-20(22(27)25-21(19)26)18-12(2)24-16-10-6-4-8-14(16)18/h3-10,23-24H,1-2H3,(H,25,26,27)
PDB

UniProtKB/SwissProt

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AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/a>2.00E+4n/an/an/an/a7.430



Laboratoires Glaxo



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Biol Chem 266: 15771-81 (1991)


BindingDB Entry DOI: 10.7270/Q2FF3QJ4
More data for this
Ligand-Target Pair