BDBM2679 3,4-bis(2-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::Bisindolyl deriv. 9
SMILES: Cc1[nH]c2ccccc2c1C1=C(C(=O)NC1=O)c1c(C)[nH]c2ccccc12
InChI Key: InChIKey=NSVKLEKFZHEGLS-UHFFFAOYSA-N
Data: 1 IC50
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine)) | BDBM2679 (3,4-bis(2-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Laboratoires Glaxo | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Biol Chem 266: 15771-81 (1991) BindingDB Entry DOI: 10.7270/Q2FF3QJ4 | |||||||||||
More data for this Ligand-Target Pair |