BDBM268063 4-(6-methoxypyridin-3-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine::US10772893, Example 95::US9549932, 95
SMILES: COc1ccc(cn1)-c1cc(nc2c(nccc12)-c1ccn[nH]1)N1CCOC[C@H]1C
InChI Key:
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ATR/ATRIP (Homo sapiens (Human)) | BDBM268063 (4-(6-methoxypyridin-3-yl)-2-[(3R)-3-methylmorpholi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To determine of binding activity of the test compounds, full-length human ATR protein was expressed and purified together with ATRIP as described abo... | US Patent US10772893 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM268063 (4-(6-methoxypyridin-3-yl)-2-[(3R)-3-methylmorpholi...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description To determine of binding activity of the test compounds, full-length human ATR protein was expressed and purified together with ATRIP as described abo... | US Patent US9549932 (2017) BindingDB Entry DOI: 10.7270/Q27S7QSC | |||||||||||
More data for this Ligand-Target Pair |