null

SMILES: Cc1n[nH]c2nc(nc(OCCCN)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1

InChI Key: InChIKey=CVWBCRURJFFDOF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 268804   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM268804 (US9718825, Example 209) Show SMILES Cc1n[nH]c2nc(nc(OCCCN)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 Show InChI InChI=1S/C21H20ClFN6O3S/c1-12-18-20(28-27-12)25-19(26-21(18)32-10-2-9-24)13-3-6-15(7-4-13)29-33(30,31)17-11-14(22)5-8-16(17)23/h3-8,11,29H,2,9-10,24H2,1H3,(H,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.5	n/a	n/a	n/a	n/a	7.4	n/a
SANOFI US Patent					Assay Description The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...				US Patent US9718825 (2017) BindingDB Entry DOI: 10.7270/Q2VM4F82
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM268804 (US9718825, Example 209) Show SMILES Cc1n[nH]c2nc(nc(OCCCN)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 Show InChI InChI=1S/C21H20ClFN6O3S/c1-12-18-20(28-27-12)25-19(26-21(18)32-10-2-9-24)13-3-6-15(7-4-13)29-33(30,31)17-11-14(22)5-8-16(17)23/h3-8,11,29H,2,9-10,24H2,1H3,(H,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01601 BindingDB Entry DOI: 10.7270/Q2P55SCW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM268804 (US9718825, Example 209) Show SMILES Cc1n[nH]c2nc(nc(OCCCN)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 Show InChI InChI=1S/C21H20ClFN6O3S/c1-12-18-20(28-27-12)25-19(26-21(18)32-10-2-9-24)13-3-6-15(7-4-13)29-33(30,31)17-11-14(22)5-8-16(17)23/h3-8,11,29H,2,9-10,24H2,1H3,(H,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01601 BindingDB Entry DOI: 10.7270/Q2P55SCW
					More data for this Ligand-Target Pair