BDBM269406 (E)-3-(4-((6-hydroxy-2- (4-hydroxy-3- methylphenyl)benzo[b] thiophen-3- yl)oxy)phenyl)acrylic acid::US10058534, 61

SMILES: Cc1cc(ccc1O)-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\C(O)=O)cc1

InChI Key: InChIKey=UFNDUDYGPWPHDE-NYYWCZLTSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 269406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM269406 ((E)-3-(4-((6-hydroxy-2- (4-hydroxy-3- methylphenyl...) Show SMILES Cc1cc(ccc1O)-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C24H18O5S/c1-14-12-16(5-10-20(14)26)24-23(19-9-6-17(25)13-21(19)30-24)29-18-7-2-15(3-8-18)4-11-22(27)28/h2-13,25-26H,1H3,(H,27,28)/b11-4+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	327	n/a	n/a	n/a	n/a	5.1	37
Novartis AG US Patent					Assay Description The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM269406 ((E)-3-(4-((6-hydroxy-2- (4-hydroxy-3- methylphenyl...) Show SMILES Cc1cc(ccc1O)-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C24H18O5S/c1-14-12-16(5-10-20(14)26)24-23(19-9-6-17(25)13-21(19)30-24)29-18-7-2-15(3-8-18)4-11-22(27)28/h2-13,25-26H,1H3,(H,27,28)/b11-4+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	327	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced transc...				J Med Chem 61: 2837-2864 (2018) Article DOI: 10.1021/acs.jmedchem.7b01682 BindingDB Entry DOI: 10.7270/Q2TB1986
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM269406 ((E)-3-(4-((6-hydroxy-2- (4-hydroxy-3- methylphenyl...) Show SMILES Cc1cc(ccc1O)-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\C(O)=O)cc1 Show InChI InChI=1S/C24H18O5S/c1-14-12-16(5-10-20(14)26)24-23(19-9-6-17(25)13-21(19)30-24)29-18-7-2-15(3-8-18)4-11-22(27)28/h2-13,25-26H,1H3,(H,27,28)/b11-4+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Plate MCF7 cells at 0.3 million cells/mL (100 l/well) in black, clear-bottom 96-well plates (Greiner, catalog number 655090) in DMEM/F12 media (Gibco...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair