BDBM269453 (E)-3-(4-((2-(5-fluoro- 2-(2,2,2- trifluoroethyl)phenyl)- 6- hydroxybenzo[b] thiophen-3- yl)oxy)phenyl)acrylic acid::US10058534, 108

SMILES: OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2cc(F)ccc2CC(F)(F)F)cc1

InChI Key: InChIKey=ZQOKBJQZFJMPHA-XCVCLJGOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269453   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM269453 ((E)-3-(4-((2-(5-fluoro- 2-(2,2,2- trifluoroethyl)p...) Show SMILES OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2cc(F)ccc2CC(F)(F)F)cc1 Show InChI InChI=1S/C25H16F4O4S/c26-16-5-4-15(13-25(27,28)29)20(11-16)24-23(19-9-6-17(30)12-21(19)34-24)33-18-7-1-14(2-8-18)3-10-22(31)32/h1-12,30H,13H2,(H,31,32)/b10-3+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Plate MCF7 cells at 0.3 million cells/mL (100 l/well) in black, clear-bottom 96-well plates (Greiner, catalog number 655090) in DMEM/F12 media (Gibco...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM269453 ((E)-3-(4-((2-(5-fluoro- 2-(2,2,2- trifluoroethyl)p...) Show SMILES OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2cc(F)ccc2CC(F)(F)F)cc1 Show InChI InChI=1S/C25H16F4O4S/c26-16-5-4-15(13-25(27,28)29)20(11-16)24-23(19-9-6-17(30)12-21(19)34-24)33-18-7-1-14(2-8-18)3-10-22(31)32/h1-12,30H,13H2,(H,31,32)/b10-3+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	5.1	37
Novartis AG US Patent					Assay Description The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...				US Patent US10058534 (2018) BindingDB Entry DOI: 10.7270/Q2M32XSG
					More data for this Ligand-Target Pair