BDBM269632 (2R)-N-(5-(5-bromo-3-pyridinyl)-4-(2,6-dimethoxyphenyl)-4H-1,2,4-triazol-3-yl)-1-(5-fluoro-2-pyrimidinyl)-2-propanesulfonamide, (2S)-N-(5-(5-bromo-3-pyridinyl)-4-(2,6-dimethoxyphenyl)-4H-1,2,4-triazol-3-yl)-1-(5-fluoro-2-pyrimidinyl)-2-propanesulfonamide::US10058550, Example 146.0::US10221162, Example 146.0::US9845310, Example 146.0

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cc(Br)ccn1

InChI Key: InChIKey=FPPNEFZMSSROBJ-ZDUSSCGKSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 269632   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM269632 ((2R)-N-(5-(5-bromo-3-pyridinyl)-4-(2,6-dimethoxyph...) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cc(Br)ccn1 |r,wU:16.17,(.98,3.12,;-.36,2.35,;-1.69,3.12,;-1.69,4.66,;-3.02,5.43,;-4.36,4.66,;-4.36,3.12,;-5.69,2.35,;-7.03,3.12,;-3.02,2.35,;-3.02,.81,;-1.78,-.1,;-.45,.67,;.89,-.1,;.12,-1.43,;1.66,-1.43,;2.22,.67,;2.22,2.21,;3.56,-.1,;4.89,.67,;6.22,-.1,;7.56,.67,;7.56,2.21,;8.89,2.98,;6.22,2.98,;4.89,2.21,;-2.25,-1.56,;-3.79,-1.56,;-4.27,-.1,;-5.81,-.1,;-6.58,1.24,;-8.12,1.24,;-8.89,2.57,;-8.89,-.1,;-8.12,-1.43,;-6.58,-1.43,)| Show InChI InChI=1S/C22H21BrFN7O4S/c1-13(9-19-26-11-15(24)12-27-19)36(32,33)30-22-29-28-21(16-10-14(23)7-8-25-16)31(22)20-17(34-2)5-4-6-18(20)35-3/h4-8,10-13H,9H2,1-3H3,(H,29,30)/t13-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.10	n/a	n/a	7.5	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...				US Patent US10058550 (2018) BindingDB Entry DOI: 10.7270/Q26T0PP0
					More data for this Ligand-Target Pair
Apelin receptor (APJ) (Homo sapiens (Human))	BDBM269632 ((2R)-N-(5-(5-bromo-3-pyridinyl)-4-(2,6-dimethoxyph...) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cc(Br)ccn1 |r,wU:16.17,(.98,3.12,;-.36,2.35,;-1.69,3.12,;-1.69,4.66,;-3.02,5.43,;-4.36,4.66,;-4.36,3.12,;-5.69,2.35,;-7.03,3.12,;-3.02,2.35,;-3.02,.81,;-1.78,-.1,;-.45,.67,;.89,-.1,;.12,-1.43,;1.66,-1.43,;2.22,.67,;2.22,2.21,;3.56,-.1,;4.89,.67,;6.22,-.1,;7.56,.67,;7.56,2.21,;8.89,2.98,;6.22,2.98,;4.89,2.21,;-2.25,-1.56,;-3.79,-1.56,;-4.27,-.1,;-5.81,-.1,;-6.58,1.24,;-8.12,1.24,;-8.89,2.57,;-8.89,-.1,;-8.12,-1.43,;-6.58,-1.43,)| Show InChI InChI=1S/C22H21BrFN7O4S/c1-13(9-19-26-11-15(24)12-27-19)36(32,33)30-22-29-28-21(16-10-14(23)7-8-25-16)31(22)20-17(34-2)5-4-6-18(20)35-3/h4-8,10-13H,9H2,1-3H3,(H,29,30)/t13-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US9845310 (2017) BindingDB Entry DOI: 10.7270/Q28P62TV
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM269632 ((2R)-N-(5-(5-bromo-3-pyridinyl)-4-(2,6-dimethoxyph...) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cc(Br)ccn1 |r,wU:16.17,(.98,3.12,;-.36,2.35,;-1.69,3.12,;-1.69,4.66,;-3.02,5.43,;-4.36,4.66,;-4.36,3.12,;-5.69,2.35,;-7.03,3.12,;-3.02,2.35,;-3.02,.81,;-1.78,-.1,;-.45,.67,;.89,-.1,;.12,-1.43,;1.66,-1.43,;2.22,.67,;2.22,2.21,;3.56,-.1,;4.89,.67,;6.22,-.1,;7.56,.67,;7.56,2.21,;8.89,2.98,;6.22,2.98,;4.89,2.21,;-2.25,-1.56,;-3.79,-1.56,;-4.27,-.1,;-5.81,-.1,;-6.58,1.24,;-8.12,1.24,;-8.89,2.57,;-8.89,-.1,;-8.12,-1.43,;-6.58,-1.43,)| Show InChI InChI=1S/C22H21BrFN7O4S/c1-13(9-19-26-11-15(24)12-27-19)36(32,33)30-22-29-28-21(16-10-14(23)7-8-25-16)31(22)20-17(34-2)5-4-6-18(20)35-3/h4-8,10-13H,9H2,1-3H3,(H,29,30)/t13-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair