BDBM269735 (1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-ethoxy-1-(5-methyl-2-pyrimidinyl)-2-propanesulfonamide::US10058550, Example 252.0::US10221162, Example 252.0::US9845310, Example 252.0

SMILES: CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1

InChI Key: InChIKey=VHQQBCNPRBCOKQ-MBSDFSHPSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 269735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM269735 ((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...) Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:4.4,3.2,(4.79,-4.69,;4.79,-3.15,;3.45,-2.38,;3.45,-.84,;2.12,-.07,;2.12,1.47,;.79,-.84,;.02,-2.17,;1.56,-2.17,;-.55,-.07,;-1.88,-.84,;-2.36,-2.3,;-3.9,-2.3,;-4.37,-.84,;-5.71,-.07,;-6.48,-1.4,;-8.02,-1.4,;-8.79,-.07,;-8.02,1.27,;-8.79,2.6,;-6.48,1.27,;-3.13,.07,;-3.13,1.61,;-1.72,2.29,;-.4,1.51,;.95,2.26,;-1.79,3.92,;-3.13,4.69,;-4.46,3.92,;-4.46,2.38,;-5.8,1.61,;-7.13,2.38,;4.79,-.07,;6.12,-.84,;7.45,-.07,;7.45,1.47,;8.79,2.24,;6.12,2.24,;4.79,1.47,)| Show InChI InChI=1S/C26H31N7O5S/c1-7-38-23(24-28-13-17(3)14-29-24)18(4)39(34,35)32-26-31-30-25(19-11-16(2)12-27-15-19)33(26)22-20(36-5)9-8-10-21(22)37-6/h8-15,18,23H,7H2,1-6H3,(H,31,32)/t18-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.800	n/a	n/a	7.5	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...				US Patent US10058550 (2018) BindingDB Entry DOI: 10.7270/Q26T0PP0
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM269735 ((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...) Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:4.4,3.2,(4.79,-4.69,;4.79,-3.15,;3.45,-2.38,;3.45,-.84,;2.12,-.07,;2.12,1.47,;.79,-.84,;.02,-2.17,;1.56,-2.17,;-.55,-.07,;-1.88,-.84,;-2.36,-2.3,;-3.9,-2.3,;-4.37,-.84,;-5.71,-.07,;-6.48,-1.4,;-8.02,-1.4,;-8.79,-.07,;-8.02,1.27,;-8.79,2.6,;-6.48,1.27,;-3.13,.07,;-3.13,1.61,;-1.72,2.29,;-.4,1.51,;.95,2.26,;-1.79,3.92,;-3.13,4.69,;-4.46,3.92,;-4.46,2.38,;-5.8,1.61,;-7.13,2.38,;4.79,-.07,;6.12,-.84,;7.45,-.07,;7.45,1.47,;8.79,2.24,;6.12,2.24,;4.79,1.47,)| Show InChI InChI=1S/C26H31N7O5S/c1-7-38-23(24-28-13-17(3)14-29-24)18(4)39(34,35)32-26-31-30-25(19-11-16(2)12-27-15-19)33(26)22-20(36-5)9-8-10-21(22)37-6/h8-15,18,23H,7H2,1-6H3,(H,31,32)/t18-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US9845310 (2017) BindingDB Entry DOI: 10.7270/Q28P62TV
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM269735 ((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...) Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:4.4,3.2,(4.79,-4.69,;4.79,-3.15,;3.45,-2.38,;3.45,-.84,;2.12,-.07,;2.12,1.47,;.79,-.84,;.02,-2.17,;1.56,-2.17,;-.55,-.07,;-1.88,-.84,;-2.36,-2.3,;-3.9,-2.3,;-4.37,-.84,;-5.71,-.07,;-6.48,-1.4,;-8.02,-1.4,;-8.79,-.07,;-8.02,1.27,;-8.79,2.6,;-6.48,1.27,;-3.13,.07,;-3.13,1.61,;-1.72,2.29,;-.4,1.51,;.95,2.26,;-1.79,3.92,;-3.13,4.69,;-4.46,3.92,;-4.46,2.38,;-5.8,1.61,;-7.13,2.38,;4.79,-.07,;6.12,-.84,;7.45,-.07,;7.45,1.47,;8.79,2.24,;6.12,2.24,;4.79,1.47,)| Show InChI InChI=1S/C26H31N7O5S/c1-7-38-23(24-28-13-17(3)14-29-24)18(4)39(34,35)32-26-31-30-25(19-11-16(2)12-27-15-19)33(26)22-20(36-5)9-8-10-21(22)37-6/h8-15,18,23H,7H2,1-6H3,(H,31,32)/t18-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair