BDBM270523 (S)-3-(((6-(2-ethylphenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)methyl)amino) isonicotinic acid::US10059687, Example 15B

SMILES: CCc1ccccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)CCc2c1

InChI Key: InChIKey=XJVCJAKSNUAJOE-XMMPIXPASA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 270523   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270523 ((S)-3-(((6-(2-ethylphenyl)-2-methyl-1,2,3,4-tetrah...) Show SMILES CCc1ccccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)CCc2c1 |r| Show InChI InChI=1S/C25H27N3O2/c1-3-17-6-4-5-7-20(17)18-8-9-21-19(14-18)11-13-28(2)24(21)16-27-23-15-26-12-10-22(23)25(29)30/h4-10,12,14-15,24,27H,3,11,13,16H2,1-2H3,(H,29,30)/t24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270523 ((S)-3-(((6-(2-ethylphenyl)-2-methyl-1,2,3,4-tetrah...) Show SMILES CCc1ccccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)CCc2c1 |r| Show InChI InChI=1S/C25H27N3O2/c1-3-17-6-4-5-7-20(17)18-8-9-21-19(14-18)11-13-28(2)24(21)16-27-23-15-26-12-10-22(23)25(29)30/h4-10,12,14-15,24,27H,3,11,13,16H2,1-2H3,(H,29,30)/t24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270523 ((S)-3-(((6-(2-ethylphenyl)-2-methyl-1,2,3,4-tetrah...) Show SMILES CCc1ccccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)CCc2c1 |r| Show InChI InChI=1S/C25H27N3O2/c1-3-17-6-4-5-7-20(17)18-8-9-21-19(14-18)11-13-28(2)24(21)16-27-23-15-26-12-10-22(23)25(29)30/h4-10,12,14-15,24,27H,3,11,13,16H2,1-2H3,(H,29,30)/t24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description Jarid1b: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction condit...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM270523 ((S)-3-(((6-(2-ethylphenyl)-2-methyl-1,2,3,4-tetrah...) Show SMILES CCc1ccccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)CCc2c1 |r| Show InChI InChI=1S/C25H27N3O2/c1-3-17-6-4-5-7-20(17)18-8-9-21-19(14-18)11-13-28(2)24(21)16-27-23-15-26-12-10-22(23)25(29)30/h4-10,12,14-15,24,27H,3,11,13,16H2,1-2H3,(H,29,30)/t24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM270523 ((S)-3-(((6-(2-ethylphenyl)-2-methyl-1,2,3,4-tetrah...) Show SMILES CCc1ccccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)CCc2c1 |r| Show InChI InChI=1S/C25H27N3O2/c1-3-17-6-4-5-7-20(17)18-8-9-21-19(14-18)11-13-28(2)24(21)16-27-23-15-26-12-10-22(23)25(29)30/h4-10,12,14-15,24,27H,3,11,13,16H2,1-2H3,(H,29,30)/t24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description JMJD3: The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of t...				US Patent US11001568 (2021)
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM270523 ((S)-3-(((6-(2-ethylphenyl)-2-methyl-1,2,3,4-tetrah...) Show SMILES CCc1ccccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)N(C)CCc2c1 |r| Show InChI InChI=1S/C25H27N3O2/c1-3-17-6-4-5-7-20(17)18-8-9-21-19(14-18)11-13-28(2)24(21)16-27-23-15-26-12-10-22(23)25(29)30/h4-10,12,14-15,24,27H,3,11,13,16H2,1-2H3,(H,29,30)/t24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54
					More data for this Ligand-Target Pair