BDBM270571 (S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)-N4-((4- methyltetrahydro- 2H-pyran-4- yl)methyl)quinazoline- 4,6-diamine::US10059695, I-3::US10577352, Compound I-3

SMILES: CC1(CNc2ncnc3ccc(NC(c4cn(nn4)C4CC4)c4ccc(F)cc4)cc23)CCOCC1

InChI Key: InChIKey=CVDCGMIOVXHTCP-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270571   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270571 ((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...) Show SMILES CC1(CNc2ncnc3ccc(NC(c4cn(nn4)C4CC4)c4ccc(F)cc4)cc23)CCOCC1 Show InChI InChI=1S/C27H30FN7O/c1-27(10-12-36-13-11-27)16-29-26-22-14-20(6-9-23(22)30-17-31-26)32-25(18-2-4-19(28)5-3-18)24-15-35(34-33-24)21-7-8-21/h2-6,9,14-15,17,21,25,32H,7-8,10-13,16H2,1H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270571 ((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...) Show SMILES CC1(CNc2ncnc3ccc(NC(c4cn(nn4)C4CC4)c4ccc(F)cc4)cc23)CCOCC1 Show InChI InChI=1S/C27H30FN7O/c1-27(10-12-36-13-11-27)16-29-26-22-14-20(6-9-23(22)30-17-31-26)32-25(18-2-4-19(28)5-3-18)24-15-35(34-33-24)21-7-8-21/h2-6,9,14-15,17,21,25,32H,7-8,10-13,16H2,1H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	296	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270571 ((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...) Show SMILES CC1(CNc2ncnc3ccc(NC(c4cn(nn4)C4CC4)c4ccc(F)cc4)cc23)CCOCC1 Show InChI InChI=1S/C27H30FN7O/c1-27(10-12-36-13-11-27)16-29-26-22-14-20(6-9-23(22)30-17-31-26)32-25(18-2-4-19(28)5-3-18)24-15-35(34-33-24)21-7-8-21/h2-6,9,14-15,17,21,25,32H,7-8,10-13,16H2,1H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270571 ((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...) Show SMILES CC1(CNc2ncnc3ccc(NC(c4cn(nn4)C4CC4)c4ccc(F)cc4)cc23)CCOCC1 Show InChI InChI=1S/C27H30FN7O/c1-27(10-12-36-13-11-27)16-29-26-22-14-20(6-9-23(22)30-17-31-26)32-25(18-2-4-19(28)5-3-18)24-15-35(34-33-24)21-7-8-21/h2-6,9,14-15,17,21,25,32H,7-8,10-13,16H2,1H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	296	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair