null

SMILES: Fc1ccc(cc1)C(Nc1ccc2ncnc(NC(CC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1

InChI Key: InChIKey=PMKQVHDRZZCGPS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270573   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270573 (3-((6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl...) Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(NC(CC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1 Show InChI InChI=1S/C29H25FN8/c30-21-8-6-20(7-9-21)28(27-17-38(37-36-27)23-11-12-23)34-22-10-13-26-24(16-22)29(33-18-32-26)35-25(14-15-31)19-4-2-1-3-5-19/h1-10,13,16-18,23,25,28,34H,11-12,14H2,(H,32,33,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270573 (3-((6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl...) Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(NC(CC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1 Show InChI InChI=1S/C29H25FN8/c30-21-8-6-20(7-9-21)28(27-17-38(37-36-27)23-11-12-23)34-22-10-13-26-24(16-22)29(33-18-32-26)35-25(14-15-31)19-4-2-1-3-5-19/h1-10,13,16-18,23,25,28,34H,11-12,14H2,(H,32,33,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270573 (3-((6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl...) Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(NC(CC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1 Show InChI InChI=1S/C29H25FN8/c30-21-8-6-20(7-9-21)28(27-17-38(37-36-27)23-11-12-23)34-22-10-13-26-24(16-22)29(33-18-32-26)35-25(14-15-31)19-4-2-1-3-5-19/h1-10,13,16-18,23,25,28,34H,11-12,14H2,(H,32,33,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270573 (3-((6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl...) Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(NC(CC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1 Show InChI InChI=1S/C29H25FN8/c30-21-8-6-20(7-9-21)28(27-17-38(37-36-27)23-11-12-23)34-22-10-13-26-24(16-22)29(33-18-32-26)35-25(14-15-31)19-4-2-1-3-5-19/h1-10,13,16-18,23,25,28,34H,11-12,14H2,(H,32,33,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair