BDBM270577 (S)-8-chloro-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl-d)-N4- neopentylquinazoline- 4,6-diamine::US10059695, I-9::US10577352, Compound I-9

SMILES: CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12

InChI Key: InChIKey=LHFXWQMDZTYDNH-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270577   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270577 ((S)-8-chloro-N6-((2- chlorophenyl)(1- cyclopropyl-...) Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12 Show InChI InChI=1S/C25H27Cl2N7/c1-25(2,3)13-28-24-18-10-15(11-20(27)22(18)29-14-30-24)31-23(17-6-4-5-7-19(17)26)21-12-34(33-32-21)16-8-9-16/h4-7,10-12,14,16,23,31H,8-9,13H2,1-3H3,(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270577 ((S)-8-chloro-N6-((2- chlorophenyl)(1- cyclopropyl-...) Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12 Show InChI InChI=1S/C25H27Cl2N7/c1-25(2,3)13-28-24-18-10-15(11-20(27)22(18)29-14-30-24)31-23(17-6-4-5-7-19(17)26)21-12-34(33-32-21)16-8-9-16/h4-7,10-12,14,16,23,31H,8-9,13H2,1-3H3,(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	86	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270577 ((S)-8-chloro-N6-((2- chlorophenyl)(1- cyclopropyl-...) Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12 Show InChI InChI=1S/C25H27Cl2N7/c1-25(2,3)13-28-24-18-10-15(11-20(27)22(18)29-14-30-24)31-23(17-6-4-5-7-19(17)26)21-12-34(33-32-21)16-8-9-16/h4-7,10-12,14,16,23,31H,8-9,13H2,1-3H3,(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270577 ((S)-8-chloro-N6-((2- chlorophenyl)(1- cyclopropyl-...) Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12 Show InChI InChI=1S/C25H27Cl2N7/c1-25(2,3)13-28-24-18-10-15(11-20(27)22(18)29-14-30-24)31-23(17-6-4-5-7-19(17)26)21-12-34(33-32-21)16-8-9-16/h4-7,10-12,14,16,23,31H,8-9,13H2,1-3H3,(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	86	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair