BDBM270579 (R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(4- fluorophenyl)methyl- d)amino)quinazolin- 4-yl)amino)-4- phenylbutanenitrile::US10059695, I-11::US10577352, Compound I-11

SMILES: Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1

InChI Key: InChIKey=LMGXIJOACLYHHX-HSLSYKTRSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270579   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270579 ((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...) Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1 |r| Show InChI InChI=1S/C30H26ClFN8/c31-25-16-22(36-28(20-8-10-21(32)11-9-20)27-17-40(39-38-27)23-12-13-23)15-24-29(25)34-18-35-30(24)37-26(7-4-14-33)19-5-2-1-3-6-19/h1-3,5-6,8-11,15-18,23,26,28,36H,4,7,12-13H2,(H,34,35,37)/t26-,28?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270579 ((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...) Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1 |r| Show InChI InChI=1S/C30H26ClFN8/c31-25-16-22(36-28(20-8-10-21(32)11-9-20)27-17-40(39-38-27)23-12-13-23)15-24-29(25)34-18-35-30(24)37-26(7-4-14-33)19-5-2-1-3-6-19/h1-3,5-6,8-11,15-18,23,26,28,36H,4,7,12-13H2,(H,34,35,37)/t26-,28?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	671	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270579 ((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...) Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1 |r| Show InChI InChI=1S/C30H26ClFN8/c31-25-16-22(36-28(20-8-10-21(32)11-9-20)27-17-40(39-38-27)23-12-13-23)15-24-29(25)34-18-35-30(24)37-26(7-4-14-33)19-5-2-1-3-6-19/h1-3,5-6,8-11,15-18,23,26,28,36H,4,7,12-13H2,(H,34,35,37)/t26-,28?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270579 ((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...) Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1 |r| Show InChI InChI=1S/C30H26ClFN8/c31-25-16-22(36-28(20-8-10-21(32)11-9-20)27-17-40(39-38-27)23-12-13-23)15-24-29(25)34-18-35-30(24)37-26(7-4-14-33)19-5-2-1-3-6-19/h1-3,5-6,8-11,15-18,23,26,28,36H,4,7,12-13H2,(H,34,35,37)/t26-,28?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	671	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair