null
SMILES: CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(C)nc12
InChI Key: InChIKey=GOJMFWHERUDAEJ-HAQNSBGRSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM270855 (US10059709, 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 838 | n/a | n/a | n/a | n/a | n/a | n/a |
Elanco Tiergesundheit AG US Patent | Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8... | US Patent US10059709 (2018) BindingDB Entry DOI: 10.7270/Q25X2BZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM270855 (US10059709, 1) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elanco Tiergesundheit AG US Patent | Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8... | US Patent US10059709 (2018) BindingDB Entry DOI: 10.7270/Q25X2BZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM270855 (US10059709, 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Elanco Tiergesundheit AG US Patent | Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8... | US Patent US10059709 (2018) BindingDB Entry DOI: 10.7270/Q25X2BZX | |||||||||||
More data for this Ligand-Target Pair |