BDBM272687 2-Amino-N-{1-[4-chloro-7-(3-methoxypyrrolidin-1- yl)-2H-indazol-6-yl]ethyl}pyrazolo[1,5- a]pyrimidine-3-carboxamide bis(trifluoroacetate)::US10065963, Example 91

SMILES: COC1CCN(C1)c1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12

InChI Key:

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 272687   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM272687 (2-Amino-N-{1-[4-chloro-7-(3-methoxypyrrolidin-1- y...) Show SMILES COC1CCN(C1)c1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	6.7	25
Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...				US Patent US10065963 (2018) BindingDB Entry DOI: 10.7270/Q2H41TFS
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM272687 (2-Amino-N-{1-[4-chloro-7-(3-methoxypyrrolidin-1- y...) Show SMILES COC1CCN(C1)c1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description To measure the Phosphorylated Ribosomal Protein S6 (RPS6) in cell lysates, THP-1 cells (Human Acute Monocytic Leukemia) are purchased from ATCC (Mana...				US Patent US10065963 (2018) BindingDB Entry DOI: 10.7270/Q2H41TFS
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM272687 (2-Amino-N-{1-[4-chloro-7-(3-methoxypyrrolidin-1- y...) Show SMILES COC1CCN(C1)c1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	6.7	25
Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...				US Patent US10065963 (2018) BindingDB Entry DOI: 10.7270/Q2H41TFS
					More data for this Ligand-Target Pair