BDBM2727 3-[2-(2-chloro-6-fluoro-3-hydroxyphenyl)cyclopropyl]-1-(5-chloropyridin-2-yl)urea::N-[cis-2-(2-Chloro-6-fluoro-3-hydroxyphenyl)cyclopropyl]-N-[2-(5-chloropyridyl)]urea::urea-PETT deriv. 12

SMILES: Oc1ccc(F)c(C2CC2NC(=O)Nc2ccc(Cl)cn2)c1Cl

InChI Key: InChIKey=NTNATEYJPONKDY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2727   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM2727 (3-[2-(2-chloro-6-fluoro-3-hydroxyphenyl)cyclopropy...) Show SMILES Oc1ccc(F)c(C2CC2NC(=O)Nc2ccc(Cl)cn2)c1Cl Show InChI InChI=1S/C15H12Cl2FN3O2/c16-7-1-4-12(19-6-7)21-15(23)20-10-5-8(10)13-9(18)2-3-11(22)14(13)17/h1-4,6,8,10,22H,5H2,(H2,19,20,21,23)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
Medivir AB					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 42: 4150-60 (1999) Article DOI: 10.1021/jm990095j BindingDB Entry DOI: 10.7270/Q25X273G
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (K103N) (Human immunodeficiency virus type 1)	BDBM2727 (3-[2-(2-chloro-6-fluoro-3-hydroxyphenyl)cyclopropy...) Show SMILES Oc1ccc(F)c(C2CC2NC(=O)Nc2ccc(Cl)cn2)c1Cl Show InChI InChI=1S/C15H12Cl2FN3O2/c16-7-1-4-12(19-6-7)21-15(23)20-10-5-8(10)13-9(18)2-3-11(22)14(13)17/h1-4,6,8,10,22H,5H2,(H2,19,20,21,23)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medivir AB					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 42: 4150-60 (1999) Article DOI: 10.1021/jm990095j BindingDB Entry DOI: 10.7270/Q25X273G
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (Y181C) (Human immunodeficiency virus type 1)	BDBM2727 (3-[2-(2-chloro-6-fluoro-3-hydroxyphenyl)cyclopropy...) Show SMILES Oc1ccc(F)c(C2CC2NC(=O)Nc2ccc(Cl)cn2)c1Cl Show InChI InChI=1S/C15H12Cl2FN3O2/c16-7-1-4-12(19-6-7)21-15(23)20-10-5-8(10)13-9(18)2-3-11(22)14(13)17/h1-4,6,8,10,22H,5H2,(H2,19,20,21,23)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medivir AB					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 42: 4150-60 (1999) Article DOI: 10.1021/jm990095j BindingDB Entry DOI: 10.7270/Q25X273G
					More data for this Ligand-Target Pair