BDBM273096 (R)-N-benzyl-1-{5-[difluoro(pyridin-2-yl)methyl]-6-methyl-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl}pyrrolidine-2-carboxamide::US10065972, Example 273

SMILES: Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)c1ccccn1

InChI Key: InChIKey=GHOHPEUPWCDQJP-MRXNPFEDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273096   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens (Human))	BDBM273096 ((R)-N-benzyl-1-{5-[difluoro(pyridin-2-yl)methyl]-6...) Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)c1ccccn1 |r| Show InChI InChI=1S/C24H22F2N6O2S/c1-31-21(34)18-20(30-22(31)24(25,26)17-11-5-6-12-27-17)35-23(29-18)32-13-7-10-16(32)19(33)28-14-15-8-3-2-4-9-15/h2-6,8-9,11-12,16H,7,10,13-14H2,1H3,(H,28,33)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	8.0	n/a
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...				US Patent US10065972 (2018) BindingDB Entry DOI: 10.7270/Q23X88P5
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