BDBM273321 8-isopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyridine::US10071079, Example 95::US10478424, Example 95

SMILES: CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C(C)C)c2ncnn2c1

InChI Key: InChIKey=IXFSDHYDZGJXSI-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 273321   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273321 (8-isopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-i...) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C(C)C)c2ncnn2c1 Show InChI InChI=1S/C25H31N5/c1-15(2)20-12-19(13-30-25(20)27-14-28-30)24-23(16(3)4)21-11-18(5-6-22(21)29-24)17-7-9-26-10-8-17/h5-6,11-17,26,29H,7-10H2,1-4H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273321 (8-isopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-i...) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C(C)C)c2ncnn2c1 Show InChI InChI=1S/C25H31N5/c1-15(2)20-12-19(13-30-25(20)27-14-28-30)24-23(16(3)4)21-11-18(5-6-22(21)29-24)17-7-9-26-10-8-17/h5-6,11-17,26,29H,7-10H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.9	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273321 (8-isopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-i...) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C(C)C)c2ncnn2c1 Show InChI InChI=1S/C25H31N5/c1-15(2)20-12-19(13-30-25(20)27-14-28-30)24-23(16(3)4)21-11-18(5-6-22(21)29-24)17-7-9-26-10-8-17/h5-6,11-17,26,29H,7-10H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.96E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM273321 (8-isopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-i...) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C(C)C)c2ncnn2c1 Show InChI InChI=1S/C25H31N5/c1-15(2)20-12-19(13-30-25(20)27-14-28-30)24-23(16(3)4)21-11-18(5-6-22(21)29-24)17-7-9-26-10-8-17/h5-6,11-17,26,29H,7-10H2,1-4H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM273321 (8-isopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-i...) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C(C)C)c2ncnn2c1 Show InChI InChI=1S/C25H31N5/c1-15(2)20-12-19(13-30-25(20)27-14-28-30)24-23(16(3)4)21-11-18(5-6-22(21)29-24)17-7-9-26-10-8-17/h5-6,11-17,26,29H,7-10H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.9	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10478424 (2019) BindingDB Entry DOI: 10.7270/Q2QZ2DB0
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM273321 (8-isopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-i...) Show SMILES CC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cc(C(C)C)c2ncnn2c1 Show InChI InChI=1S/C25H31N5/c1-15(2)20-12-19(13-30-25(20)27-14-28-30)24-23(16(3)4)21-11-18(5-6-22(21)29-24)17-7-9-26-10-8-17/h5-6,11-17,26,29H,7-10H2,1-4H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.96E+3	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10071079 (2018) BindingDB Entry DOI: 10.7270/Q2VD71GV
					More data for this Ligand-Target Pair