BDBM27437 12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-6-amine::pyrido-thieno-pyrimidine, 6k

SMILES: Nc1ncnc2c3cc(cnc3sc12)-c1ccccc1

InChI Key: InChIKey=KOEWWBBSRQMABA-UHFFFAOYSA-N

Data: 1 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 27437   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cdc7 Kinase (Homo sapiens (Human))	BDBM27437 (12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...) Show SMILES Nc1ncnc2c3cc(cnc3sc12)-c1ccccc1 Show InChI InChI=1S/C15H10N4S/c16-14-13-12(18-8-19-14)11-6-10(7-17-15(11)20-13)9-4-2-1-3-5-9/h1-8H,(H2,16,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	900	-8.57	9.00E+3	n/a	n/a	n/a	n/a	7.5	37
Roche					Assay Description The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...				Bioorg Med Chem Lett 19: 319-23 (2009) Article DOI: 10.1016/j.bmcl.2008.11.093 BindingDB Entry DOI: 10.7270/Q20G3HG2
					More data for this Ligand-Target Pair
Dual specificty protein kinase CLK1 (Homo sapiens (Human))	BDBM27437 (12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...) Show SMILES Nc1ncnc2c3cc(cnc3sc12)-c1ccccc1 Show InChI InChI=1S/C15H10N4S/c16-14-13-12(18-8-19-14)11-6-10(7-17-15(11)20-13)9-4-2-1-3-5-9/h1-8H,(H2,16,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
UMR 6014& FR 3038; Univ Rouen; INSA Rouen; CNRS Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 mins				Eur J Med Chem 92: 124-34 (2015) Article DOI: 10.1016/j.ejmech.2014.12.038 BindingDB Entry DOI: 10.7270/Q2BR8TVG
					More data for this Ligand-Target Pair
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (RAT)	BDBM27437 (12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...) Show SMILES Nc1ncnc2c3cc(cnc3sc12)-c1ccccc1 Show InChI InChI=1S/C15H10N4S/c16-14-13-12(18-8-19-14)11-6-10(7-17-15(11)20-13)9-4-2-1-3-5-9/h1-8H,(H2,16,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
UMR 6014& FR 3038; Univ Rouen; INSA Rouen; CNRS Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 30 mins by scintillation counti...				Eur J Med Chem 92: 124-34 (2015) Article DOI: 10.1016/j.ejmech.2014.12.038 BindingDB Entry DOI: 10.7270/Q2BR8TVG
					More data for this Ligand-Target Pair