BDBM274442 N-(6-(4-(4-fluorophenyl)-1-(1- methylpiperidin-4-yl)-1H-imidazol-5- yl)imidazo[1,2-6]pyridazin-2- yl)isonicotinamide::US9556179, Compound 11

SMILES: CN1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1

InChI Key: InChIKey=YOYUCXRORDPXQJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274442   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274442 (N-(6-(4-(4-fluorophenyl)-1-(1- methylpiperidin-4-y...) Show SMILES CN1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C27H24F2N8O/c1-35-12-9-20(10-13-35)36-16-31-25(17-2-4-19(28)5-3-17)26(36)21-6-7-24-32-23(15-37(24)34-21)33-27(38)18-8-11-30-22(29)14-18/h2-8,11,14-16,20H,9-10,12-13H2,1H3,(H,33,38)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.847	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274442 (N-(6-(4-(4-fluorophenyl)-1-(1- methylpiperidin-4-y...) Show SMILES CN1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C27H24F2N8O/c1-35-12-9-20(10-13-35)36-16-31-25(17-2-4-19(28)5-3-17)26(36)21-6-7-24-32-23(15-37(24)34-21)33-27(38)18-8-11-30-22(29)14-18/h2-8,11,14-16,20H,9-10,12-13H2,1H3,(H,33,38)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.654	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair