BDBM274514 US9556179, Compound 84::methyl 4-(5-(2-(2- fluoroisonicotinamido)imidazo[1,2- b]pyridazin-6-yl)-4-(4-fluorophenyl)- 1H-imidazol-1-yl)piperidine-1- carboxylate

SMILES: COC(=O)N1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1

InChI Key: InChIKey=UEMQWZBFDVAUQH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM274514 (US9556179, Compound 84 | methyl 4-(5-(2-(2- fluoro...) Show SMILES COC(=O)N1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C28H24F2N8O3/c1-41-28(40)36-12-9-20(10-13-36)37-16-32-25(17-2-4-19(29)5-3-17)26(37)21-6-7-24-33-23(15-38(24)35-21)34-27(39)18-8-11-31-22(30)14-18/h2-8,11,14-16,20H,9-10,12-13H2,1H3,(H,34,39)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.179	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Homo sapiens (Human))	BDBM274514 (US9556179, Compound 84 | methyl 4-(5-(2-(2- fluoro...) Show SMILES COC(=O)N1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C28H24F2N8O3/c1-41-28(40)36-12-9-20(10-13-36)37-16-32-25(17-2-4-19(29)5-3-17)26(37)21-6-7-24-33-23(15-38(24)35-21)34-27(39)18-8-11-31-22(30)14-18/h2-8,11,14-16,20H,9-10,12-13H2,1H3,(H,34,39)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.967	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...				US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5
					More data for this Ligand-Target Pair